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2016 Mayfield Football Schedule
| DATE | OPPONENT | SITE | GAME TIME | RESULTS | VIDEO |
| Aug 19, 2016 | Ft. Campbell | HOME | 7:00 | (W) 56-0 | |
| Aug 26, 2016 | Marshall County | HOME | 7:00 | (W) 48-7 | |
| Sep 2, 2016 | Paducah Tilghman | HOME | 7:00 | (W) 48-26 | |
| Sep 9, 2016 | McCracken County | AWAY | 7:00 | (W) 46-41 | |
| Sep 16, 2016 | Graves County | AWAY | 7:00 | (W) 42-14 | |
| Sep 23, 2016 | Corbin | AWAY - Lindsey Wilson College | 7:00 | (W) 35-34 | |
| Sep 30, 2016 | Murray | AWAY | 7:00 | (W) 49-7 | |
| Oct 7, 2016 | OPEN | | | | |
| Oct 14, 2016 | Ballard Memorial | AWAY | 7:00 | (W) 52-0 | |
| Oct 21, 2016 | Webster County | HOME | 7:30 | (W) 57-0 | |
| Oct 28, 2016 | Caldwell County | HOME | 7:00 | (W) 57-27 | |
| Nov 4, 2016 | Hancock County | HOME | 7:30 | (W) 55-7 | |
| Nov 11, 2016 | Butler County | HOME | 7:00 | (W) 49-6 | |
| Nov 18, 2016 | Owensboro Catholic | AWAY KWC Steele Field | 7:00 | (W) 28-6 | |
| Nov 25, 2016 | Christian Academy Louisville | AWAY Centurion Field | 7:30 EST | (L) 48-24 | |
| TBD | Round 5 KHSAA | TBD | TBD | | |