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2021 Mayfield Football Schedule
| DATE | OPPONENT | SITE | GAME TIME | RESULTS | VIDEO |
| Aug 20, 2021 | Graves County | HOME | 7:00 | W 35-21 | Video |
| Aug 27, 2021 | Hopkinsville | AWAY | 7:00 | W 21-3 | Video |
| Sep 3, 2021 | Paducah Tilghman | AWAY | 7:00 | W 42-28 | Video |
| Sep 10, 2021 | McCracken County | HOME | 7:00 | W 32-14 | Video |
| Sep 17, 2021 | Calloway County | HOME | 7:00 | W 55-13 | Video |
| Sep 24, 2021 | Fort Campbell | AWAY | 7:00 | W 55-0 | Video |
| Oct 1, 2021 | Caldwell County | AWAY | 7:00 | W 35-16 | Video |
| Oct 15, 2021 | Ballard County | HOME | 7:00 | W 70-6 | Video |
| Oct 22, 2021 | Murray | HOME | 7:00 | L 25-21 | Video |
| Oct 29, 2021 | Madisonville | AWAY | 7:00 | W 50-23 | Video |
| Nov 5, 2021 | Ballard | HOME | 7:00 | W 60-0 | Video |
| Nov 12, 2021 | Murray | HOME | 7:00 | W 55-6 | Video |
| Nov 19, 2021 | Green County | HOME | 6:30 | W 48-6 | Video |
| Nov 26, 2021 | Beechwood | AWAY | 6:00 | L 38-7 | Video
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